Depression of central respiratory drive by nitrazepam.
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چکیده
منابع مشابه
Depression of central respiratory drive by nitrazepam.
In a group of patients with chronic bronchitis, repeated night sedation with 10 mg nitrazepam produced a fall in central respiratory drive and a steady rise in arterial carbon dioxide tension. The changes produced over a five-day period were not clinically important, except in two patients who were already hypercapnic before receiving nitrazepam. The use of this drug in patients with carbon dio...
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The respiratory effects of premedication with i.v. injection of diazepam have been assessed in 10 healthy patients awaiting minor operative procedures. Measurements were recorded before and 60 min after administration of diazepam 0.14 mg kg-1. Mouth occlusion pressure (P 0.1) was used as an index of neuromuscular inspiratory drive. Minute-ventilation (VE), respiratory frequency (f) and mean ins...
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BACKGROUND The contribution of the central respiratory drive in the hypercapnic respiratory failure of neuromuscular diseases (NMD) is controversial. OBJECTIVE To compare the CO2 response and the duration of weaning of mechanical ventilation between a group of NMD patients and a group of quadriplegic patients due to ICU-acquired weakness (ICU-AW). METHODS We prospectively studied 16 subject...
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Morphine is often used in cancer pain and postoperative analgesic management but induces respiratory depression. Therefore, there is an ongoing search for drug candidates that can antagonize morphine-induced respiratory depression but have no effect on morphine-induced analgesia. Acetylcholine is an excitatory neurotransmitter in central respiratory control and physostigmine antagonizes morphin...
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ژورنال
عنوان ژورنال: Thorax
سال: 1978
ISSN: 0040-6376
DOI: 10.1136/thx.33.1.97